NILE CHEMICALS

TRIS BUFFER

1. Product Identification

Synonyms: TRIS; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; THAM; Tromethamine (USP); TRIS (Base); Trisamine
CAS No.: 77-86-1
Molecular Weight: 121.14
Chemical Formula: H2NC(CH2OH)3

2. Composition/Information on Ingredients

 
  Ingredient                                CAS No         Percent        Hazardous                                 
  ---------------------------------------   ------------   ------------   ---------  
  Tris                                      77-86-1          99 - 100%       Yes                                                                   
 

3. Hazards Identification

-----------------------------------------------------------------------------------------------------------
Health Rating: 1 - Slight
Flammability Rating: 1 - Slight
Reactivity Rating: 1 - Slight
Contact Rating: 2 - Moderate
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color Code: Green (General Storage)
-----------------------------------------------------------------------------------------------------------
Potential Health Effects
----------------------------------
Inhalation: Causes irritation to the respiratory tract. Symptoms may include coughing, shortness of breath.
Ingestion: Mild alkali. Causes irritation and reddening to the mucous membranes of the mouth, esophagus, and gastrointestinal tract. Symptoms may include nausea, vomiting and diarrhea. Large oral doses may cause weakness, collapse, blood clotting and coma. Estimated lethal dose: 50 grams.
Skin Contact: Causes irritation to skin. Symptoms include redness, itching, and pain.
Eye Contact: Causes irritation, redness, and pain.
Chronic Exposure: Chronic dermatitis may follow skin contact.
Aggravation of Pre-existing Conditions: No information found.

4. First Aid Measures

Inhalation:Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion:Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact:Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.

5. Fire Fighting Measures

Fire:As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source. Slight fire hazard when exposed to heat or flame.
Explosion:Not considered to be an explosion hazard.
Fire Extinguishing Media:Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode.

6. Accidental Release Measures

Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Pick up and place in a suitable container for reclamation or disposal, using a method that does not generate dust.

7. Handling and Storage

Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Isolate from any source of heat or ignition. Isolate from oxidizing materials. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits:None established.
Ventilation System:A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:Wear protective gloves and clean body-covering clothing.
Eye Protection:Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance: Transparent, colorless crystals.
Odor: Slight characteristic odor.
Solubility: 550 mg/mL
Density: No information found.
pH: 10.4 (0.1 molar solution)
% Volatiles by volume @ 21C (70F): 0
Boiling Point: 219 - 220C (426 - 428F)
Melting Point: 171 - 172C (340 - 342F)
Vapor Density (Air=1): No information found.
Vapor Pressure (mm Hg): No information found.
Evaporation Rate (BuAc=1): No information found.

10. Stability and Reactivity

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous Polymerization: Will not occur.
Incompatibilities: Copper, brass, aluminum, and oxidizing agents.
Conditions to Avoid: Heat, incompatibles.

11. Toxicological Information


Tris: oral rat LD50: 5900 mg/kg.
  --------\Cancer Lists\------------------------------------------------------
                                         ---NTP Carcinogen---
  Ingredient                             Known    Anticipated    IARC Category
  ------------------------------------   -----    -----------    -------------
  Tris (77-86-1)                          No          No            None

12. Ecological Information

Environmental Fate: No information found.
Environmental Toxicity: No information found.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

Not regulated.

15. Regulatory Information

 
  --------\Chemical Inventory Status - Part 1\---------------------------------
  Ingredient                                       TSCA  EC   Japan  Australia
  -----------------------------------------------  ----  ---  -----  ---------
  Tris (77-86-1)                                    Yes  Yes   Yes      Yes                                     
 
  --------\Chemical Inventory Status - Part 2\---------------------------------
                                                          --Canada--
  Ingredient                                       Korea  DSL   NDSL  Phil.
  -----------------------------------------------  -----  ---   ----  -----
  Tris (77-86-1)                                    Yes   Yes   No     Yes                                                                  
 
  --------\Federal, State & International Regulations - Part 1\----------------
                                             -SARA 302-    ------SARA 313------
  Ingredient                                 RQ    TPQ     List  Chemical Catg.
  -----------------------------------------  ---   -----   ----  --------------
  Tris (77-86-1)                             No    No      No         No
 
  --------\Federal, State & International Regulations - Part 2\----------------
                                                        -RCRA-    -TSCA-
  Ingredient                                 CERCLA     261.33     8(d)
  -----------------------------------------  ------     ------    ------
  Tris (77-86-1)                             No         No         No                                                            
Chemical Weapons Convention:  No     TSCA 12(b):  No     CDTA:  No
SARA 311/312:  Acute: Yes      Chronic: No   Fire: No  Pressure: No
Reactivity: No          (Pure / Solid)

Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information

Disclaimer: Nile Chemicals. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. NILE CHEMICALS. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, NILE CHEMICALS. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.

 

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