NILE
CHEMICALS
NILE
CHEMICALS
Section
1: Chemical Product and Company Identification
Product
Name: Papain
CAS#:
9001-73-4
Synonym:
Arbuz, Caroid, Nematolyt,
Papayotin,Summetrin, Tromasin, Vegetable pepsin, Velardon,
Vermizym;
Papain, 200 milk clotting units/g
Chemical
Name: Papain
Section
2: Composition and Information on Ingredients Composition:
Name
CAS #
% by Weight
Papain
9001-73-4
100
Toxicological
Data on Ingredients: Papain,
200 mcu: ORAL (LD50): Acute: 4000 mg/kg [Rat]. 12500 mg/kg [Mouse].
Section
3: Hazards Identification Potential Acute Health Effects:
Hazardous
in case of eye contact (irritant), of inhalation. Slightly hazardous in case of
skin contact (irritant), of ingestion.
Potential
Chronic Health Effects:
CARCINOGENIC
EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS:
Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged
exposure is not known to aggravate medical condition.
Section
4: First Aid Measures Eye Contact:
Check
for and remove any contact lenses. In case of contact, immediately flush eyes
with plenty of water for at least 15 minutes. Cold water may be used. Get
medical attention.
Skin
Contact:Wash with soap and
water. Cover the irritated skin with an emollient. Get medical attention if
irritation develops. Cold water may be used.
Serious
Skin Contact: Not
available.
Inhalation:
If inhaled, remove to
fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Get medical attention.
Serious
Inhalation: Not available.
Ingestion:
Do NOT induce vomiting
unless directed to do so by medical personnel. Never give anything by mouth to
an unconscious person. If large quantities of this material are swallowed, call
a physician immediately. Loosen tight clothing such as a collar, tie, belt or
waistband.
Serious
Ingestion: Not available.
Section
5: Fire and Explosion Data
Flammability
of the Product: May be
combustible at high temperature.
Auto-Ignition
Temperature: Not
available.
Flash
Points: Not available.
Flammable
Limits: Not available.
Products
of Combustion: Not
available.
Fire
Hazards in Presence of Various Substances: Slightly
flammable to flammable in presence of open flames and sparks, of heat.
Explosion
Hazards in Presence of Various Substances:
Risks
of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not
available.
Fire
Fighting Media and Instructions:
SMALL
FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not
use water jet.
Special
Remarks on Fire Hazards: Not
available.
Special
Remarks on Explosion Hazards: Not
available.
Section
6: Accidental Release Measures Small Spill:
Use
appropriate tools to put the spilled solid in a convenient waste disposal
container. Finish cleaning by spreading water on the contaminated surface and
dispose of according to local and regional authority requirements.
Large
Spill: Use a shovel to put
the material into a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and allow to evacuate through the
sanitary system.
Section
7: Handling and Storage Precautions:
Keep
away from heat. Keep away from sources of ignition. Ground all equipment
containing material. Do not breathe dust. Avoid contact with eyes. Wear suitable
protective clothing. In case of insufficient ventilation, wear suitable
respiratory equipment. If you feel unwell, seek medical attention and show the
label when possible.
Storage:
Keep container tightly
closed. Keep container in a cool, well-ventilated area. Do not store above 8°C
(46.4°F). Refrigerate
Section
8: Exposure Controls/Personal Protection Engineering Controls:
Use
process enclosures, local exhaust ventilation, or other engineering controls to
keep airborne levels below recommended exposure limits. If user operations
generate dust, fume or mist, use ventilation to keep exposure to airborne
contaminants below the exposure limit.
Personal
Protection:Splash goggles.
Lab coat. Dust respirator. Be sure to use an approved/certified respirator or
equivalent. Gloves.
Personal
Protection in Case of a Large Spill:Splash
goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing
apparatus should be used to avoid inhalation of the product. Suggested
protective clothing might not be sufficient; consult a specialist BEFORE
handling this product.
Exposure
Limits: Not available.
Section
9: Physical and Chemical Properties
Physical
state and appearance: Solid.
(Powdered solid.)
Odor:
Not available.
Taste:
Not available.
Molecular
Weight: Not available.
Color:
Grayish white.
pH
(1% soln/water): Not
available.
Boiling
Point: Not available.
Melting
Point: Not available.
Critical
Temperature: Not
available.
Specific
Gravity: Not available.
Vapor
Pressure: Not applicable.
Vapor
Density: Not available.
Volatility:
Not available.
Odor
Threshold: Not available.
Water/Oil
Dist. Coeff.: Not
available.
Ionicity
(in Water): Not available.
Dispersion
Properties: See solubility
in water.
Solubility:
Soluble in cold water.
Section
10: Stability and Reactivity Data
Stability:
The product is stable.
Instability
Temperature: Not
available.
Conditions
of Instability: Excess
heat, dust generation, incompatible materials
Incompatibility
with various substances: Not
available.
Corrosivity:
Non-corrosive in presence
of glass.
Special
Remarks on Reactivity: Sensitive
to light.
Special
Remarks on Corrosivity: Not
available.
Polymerization:
Will not occur.
Section
11: Toxicological Information
Routes
of Entry: Inhalation.
Ingestion.
Toxicity
to Animals: Acute oral
toxicity (LD50): 4000 mg/kg [Rat].
Chronic
Effects on Humans: Not
available.
Other
Toxic Effects on Humans:
Hazardous
in case of skin contact (irritant), of inhalation (lung irritant, lung
sensitizer). Slightly hazardous in case of ingestion,.
Special
Remarks on Toxicity to Animals: Not
available.
Special
Remarks on Chronic Effects on Humans:
May
cause adverse reproductive effects and birth defects (teratogenic) based on
animal test data. No human data found.
Special
Remarks on other Toxic Effects on Humans:
Acute
Potential Health Effects: Skin: Causes skin irritation. Eyes: Causes eye
irritation. Symptoms may include coughing, wheezing, and/orshortness of breath
(dyspnea) Inhalation: Causes respiratory tract and mucous membrane irritation.
Symptoms may include coughing, wheezing. Exposure to airborne papain may also
elicit type I hypersensitivity reactions and asthmatic symptoms. Ingestion: May
cause stomach upset, hypermotility and diarrhea. Chronic Potential Health
Effects: Inhalation: Prolonged or repeated inhalation may cause emphysema.
Section
12: Ecological Information
Ecotoxicity:
Not available.
BOD5
and COD: Not available.
Products
of Biodegradation:
Possibly
hazardous short term degradation products are not likely. However, long term
degradation products may arise.
Toxicity
of the Products of Biodegradation: Not
available.
Special
Remarks on the Products of Biodegradation: Not
available.
Section
13: Disposal Considerations
Waste
Disposal:
Waste
must be disposed of in accordance with federal, state and local environmental
control regulations.
Section
14: Transport Information
DOT
Classification: Not a DOT
controlled material
Identification:
Not applicable.
Special
Provisions for Transport: Not
applicable.
Section
15: Other Regulatory Information
Federal
and State Regulations: TSCA
8(b) inventory: Papain
Other
Regulations: Not
available.
Other
Classifications:
WHMIS
(Canada): Not controlled
under WHMIS (Canada).
DSCL
(EEC):
R36/37/38-
Irritating to eyes, respiratory system and skin. R42- May cause sensitization by
inhalation. S22- Do not breathe dust. S24- Avoid contact with skin. S26- In case
of contact with eyes, rinse immediately with plenty of water and seek medical
advice. S36/37- Wear suitable protective clothing and gloves.
HMIS
(U.S.A.):
Health
Hazard: 2
Fire
Hazard: 1
Reactivity:
0
Personal
Protection: E
National
Fire Protection Association (U.S.A.):
Health:
2
Flammability:
1
Reactivity:
0
Specific
hazard:
Protective
Equipment:
Gloves.
Lab coat. Dust respirator. Be sure to use an approved/certified respirator or
equivalent. Splash goggles.
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