NILE
CHEMICALS
NILE
CHEMICALS
L-TRYPTOPHAN
Section
1: Chemical Product and Company Identification
Product
Name: L-Tryptophan
CAS#:
73-22-3
Synonym:
Tryptophan;
L-alpha-aminoindole-3-propionic acid; (-)-Tryptophan;
(S)-alpha-Amino-1H-indole-3-propanoic acid; (S)-alpha-Aminoindole-3-propionic
acid; (S)-Tryptophan; 1-beta-3-Indolylalanine; 1H-Indole-3-alanine, (S)-;
1H-Indole-3-propanoic acid, alpha-amino-, (S)-; 2-Amino-3-indolypropanoic acid;
3-Indol-3-ylalanine; Alanine, 3-indol-3-yl; L-Tryptophane; L-alpha-Amino-3-
indolepropionic
Acid; Indole-3-alanine; Propionic acid, 2-amino-3-indol-3-yl; Tryptophane;
L-Tryptofan
Chemical
Name: L-Tryptophan
Chemical
Formula: C11-H12-N2-O2
Section
2: Composition and Information on Ingredients Composition:
Name
CAS # % by Weight
{L-}Tryptophan
73-22-3 100
Toxicological
Data on Ingredients: Not
applicable.
Section
3: Hazards Identification
Potential
Acute Health Effects: Slightly
hazardous in case of skin contact (irritant), of eye contact (irritant), of
ingestion, of inhalation.
Potential
Chronic Health Effects:CARCINOGENIC
EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
Section
4: First Aid Measures Eye Contact:Check
for and remove any contact lenses. In case of contact, immediately flush eyes
with plenty of water for at least 15 minutes. Cold water may be used. Get
medical attention if irritation occurs.
Skin
Contact: Wash with soap
and water. Cover the irritated skin with an emollient. Get medical attention if
irritation develops. Cold water may be used.
Serious
Skin Contact: Not
available.
Inhalation:
If inhaled, remove to
fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Get medical attention.
Serious
Inhalation: Not available.
Ingestion:
Do NOT induce vomiting
unless directed to do so by medical personnel. Never give anything by mouth to
an unconscious person. Loosen tight clothing such as a collar, tie, belt or
waistband. Get medical attention if symptoms appear.
Serious
Ingestion: Not available.
Section
5: Fire and Explosion Data
Flammability
of the Product: May be
combustible at high temperature.
Auto-Ignition
Temperature: Not
available.
Flash
Points: Not available.
Flammable
Limits: Not available.
Products
of Combustion: These
products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).
Fire
Hazards in Presence of Various Substances:
Slightly
flammable to flammable in presence of heat. Non-flammable in presence of
oxidizing materials.
Explosion
Hazards in Presence of Various Substances:
Slightly
explosive in presence of open flames and sparks. Non-explosive in presence of
shocks.
Fire
Fighting Media and Instructions: SMALL
FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not
use water jet.
Special
Remarks on Fire Hazards: As
with most organic solids, fire is possible at elevated temperatures
Special
Remarks on Explosion Hazards: Fine
dust dispersed in air in sufficient concentrations, and in the presences of an
ignition source is a potential dust explosion hazard.
Section
6: Accidental Release Measures Small Spill:
Use
appropriate tools to put the spilled solid in a convenient waste disposal
container. Finish cleaning by spreading water on the contaminated surface and
dispose of according to local and regional authority requirements.
Large
Spill: Use a shovel to put
the material into a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and allow to evacuate through the
sanitary system.
Section
7: Handling and Storage Precautions:
Keep
away from heat. Keep away from sources of ignition. Do not ingest. Do not
breathe dust. Wear suitable protective clothing. If ingested, seek medical
advice immediately and show the container or the label. Keep away from
incompatibles such as oxidizing agents, acids.
Storage:
Keep container tightly
closed. Keep container in a cool, well-ventilated area.
Section
8: Exposure Controls/Personal Protection Engineering Controls:
Use
process enclosures, local exhaust ventilation, or other engineering controls to
keep airborne levels below recommended exposure limits. If user operations
generate dust, fume or mist, use ventilation to keep exposure to airborne
contaminants below the exposure limit.
Personal
Protection: Safety
glasses. Lab coat. Dust respirator. Be sure to use an approved/certified
respirator or equivalent. Gloves.
Personal
Protection in Case of a Large Spill:
Splash
goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing
apparatus should be used to avoid inhalation of the product. Suggested
protective clothing might not be sufficient; consult a specialist BEFORE
handling this product.
Exposure
Limits: Not available.
Section
9: Physical and Chemical Properties
Physical
state and appearance: Solid.
(Crystalline solid.)
Odor:
Odorless.
Taste:
Bitter. (Slight.)
Molecular
Weight: 204.22 g/mole
Color:
White. White to yellowish.
pH
(1% soln/water): 5.5 - 7.0
Boiling
Point: Not available.
Melting
Point:
Melting
Point: 282 deg. C Decomposition temperature: 289°C (552.2°F)
Critical
Temperature: Not
available.
Specific
Gravity: Not available.
Vapor
Pressure: Not applicable.
Vapor
Density: Not available.
Volatility:
Not available.
Odor
Threshold: Not available.
Water/Oil
Dist. Coeff.: Not
available.
Ionicity
(in Water): Not available.
Dispersion
Properties: See solubility
in water.
Solubility:
Soluble in hot water.
Partially soluble in cold water. Insoluble in diethyl ether. Slightly soluble in
acetic acid. Solubility in water: 0.23 g/l @ 0 deg. C; 11.4 g/l @ 25 deg C; 17.1
g'l @ 50 deg. C; 27.95 g/l @ 75 deg. C; 49.9 g/l @ 100 deg. C Insoluble in
chloroform. Soluble in hot alcohol and solutions of dilute acids, and alkali
hydroxides.
Section
10: Stability and Reactivity Data
Stability:
The product is stable.
Instability
Temperature: Not
available.
Conditions
of Instability: Excess
heat, incompatible materials
Incompatibility
with various substances: Reactive
with oxidizing agents, acids.
Corrosivity:
Non-corrosive in presence
of glass.
Special
Remarks on Reactivity: Protect
from light
Special
Remarks on Corrosivity: Not
available.
Polymerization:
Will not occur.
Section
11: Toxicological Information
Routes
of Entry: Inhalation.
Ingestion.
Toxicity
to Animals: Acute oral
toxicity (LD50): >16000 mg/kg [Rat].
Chronic
Effects on Humans: MUTAGENIC
EFFECTS: Mutagenic for bacteria and/or yeast.
Other
Toxic Effects on Humans: Slightly
hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special
Remarks on Toxicity to Animals: Not
available.
Special
Remarks on Chronic Effects on Humans:
May
cause adverse reproductive effects based on animal test data. May cause cancer
based on animal test data. May affect genetic material (mutagenic)
Special
Remarks on other Toxic Effects on Humans: Acute
Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye
irritation. Inhalation: May cause respiratory tract irritation. Ingestion:
Causes severe initial nausea. May affect behavior/central nervous system
(drowsiness,
headache,
excitement, somnolence, insomnia, muscle weakness, anitanxiety), respiration
(acute pulmonary edema), skin (dermatitis). May affect blood and cause
L-Tryptophan induced eosinophilia myalgia syndrome. This illness is
characterized by musculoskeletal symptoms including myalgias, arthralgias, and
paresthesias. The physical findings consist of muscle tenderness, neuropathies,
rash, peripheral and periorbital edema, eosinophilia. Chronic Potential Health
Effects: Ingestion: Prolonged or repeated ingestion may affect the liver,
metabolism (weight loss), blood (changes in red blood cell count, eosinophilia),
and respiration (dyspena, chronic pulmonary edema), urinary system.
Section
12: Ecological Information
Ecotoxicity:
Not available.
BOD5
and COD: Not available.
Products
of Biodegradation:
Possibly
hazardous short term degradation products are not likely. However, long term
degradation products may arise.
Toxicity
of the Products of Biodegradation: The
product itself and its products of degradation are not toxic.
Special
Remarks on the Products of Biodegradation: Not
available.
Section
13: Disposal Considerations
Waste
Disposal:
Waste
must be disposed of in accordance with federal, state and local environmental
control regulations.
Section
14: Transport Information
DOT
Classification: Not a DOT
controlled material (United States).
Identification:
Not applicable.
Special
Provisions for Transport: Not
applicable.
Section
15: Other Regulatory Information
Federal
and State Regulations: TSCA
8(b) inventory: L-Tryptophan
Other
Regulations: EINECS: This
product is on the European Inventory of Existing Commercial Chemical Substances.
Other
Classifications:
WHMIS
(Canada): Not controlled
under WHMIS (Canada).
DSCL
(EEC): This product is not
classified according to the EU regulations. S24/25- Avoid contact with skin and
eyes.
HMIS
(U.S.A.):
Health
Hazard: 1
Fire
Hazard: 1
Reactivity:
0
Personal
Protection: E
National
Fire Protection Association (U.S.A.):
Health:
1
Flammability:
1
Reactivity:
0
Specific
hazard:
Protective
Equipment: Gloves. Lab
coat. Dust respirator. Be sure to use an approved/certified respirator or
equivalent. Safety glasses.
Disclaimer: Nile Chemicals. provides the
information contained herein in good faith but makes no representation as to its
comprehensiveness or accuracy. This document is intended only as a guide to the
appropriate precautionary handling of the material by a properly trained person
using this product. Individuals receiving the information must exercise their
independent judgment in determining its appropriateness for a particular
purpose. NILE CHEMICALS. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS
OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH
HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, NILE
CHEMICALS. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE
UPON THIS INFORMATION.
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