NILE CHEMICALS
Section
1: Chemical Product and Company Identification
Product
Name: Cycloheximide
CAS#:
66-81-9
Synonym:
4-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
Chemical
Name: Cycloheximide
Chemical
Formula: C15-H23-N-O4
Section
2: Composition and Information on Ingredients Composition:
Name
CAS # % by Weight
Cycloheximide
66-81-9 100
Toxicological
Data on Ingredients: Cycloheximide:
ORAL (LD50): Acute: 2 mg/kg [Rat]. 133 mg/kg [Mouse]. 65 mg/kg
[Guinea
pig].
Section
3: Hazards Identification Potential Acute Health Effects:
Very
hazardous in case of skin contact (irritant), of eye contact (irritant), of
ingestion, of inhalation. Severe over-exposure can result in death. Inflammation
of the eye is characterized by redness, watering, and itching. Skin inflammation
is characterized by itching, scaling, reddening, or, occasionally, blistering.
Potential
Chronic Health Effects: CARCINOGENIC
EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS:
Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive
system/toxin/female, Development toxin [POSSIBLE]. The substance is toxic to the
nervous system, liver. The substance may be toxic to blood, kidneys,
gastrointestinal tract, skin. Repeated or prolonged exposure to the substance
can produce target organs damage. Repeated exposure to a highly toxic material
may produce general deterioration of health by an accumulation in one or many
human organs.
Section
4: First Aid Measures Eye Contact:
Check
for and remove any contact lenses. In case of contact, immediately flush eyes
with plenty of water for at least 15 minutes. Cold water may be used. WARM water
MUST be used. Get medical attention immediately.
Skin
Contact: In case of
contact, immediately flush skin with plenty of water for at least 15 minutes
while removing contaminated clothing and shoes. Cover the irritated skin with an
emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get
medical attention immediately.
Serious
Skin Contact: Wash with a
disinfectant soap and cover the contaminated skin with an anti-bacterial cream.
Seek immediate medical attention.
Inhalation:
If inhaled, remove to
fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Get medical attention.
Serious
Inhalation: Evacuate the
victim to a safe area as soon as possible. Loosen tight clothing such as a
collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If
the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical
attention.
Ingestion:
If swallowed, do not
induce vomiting unless directed to do so by medical personnel. Never give
anything by mouth to an unconscious person. Loosen tight clothing such as a
collar, tie, belt or waistband. Get medical attention immediately.
Serious
Ingestion: Not available.
Section
5: Fire and Explosion Data
Flammability
of the Product: May be
combustible at high temperature.
Auto-Ignition
Temperature: Not
available.
Flash
Points: Not available.
Flammable
Limits: Not available.
Products
of Combustion: These
products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).
Fire
Hazards in Presence of Various Substances: Not
available.
Explosion
Hazards in Presence of Various Substances:
Risks
of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not
available.
Fire
Fighting Media and Instructions: SMALL
FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not
use water jet.
Special
Remarks on Fire Hazards: Not
available.
Special
Remarks on Explosion Hazards: Not
available.
Section
6: Accidental Release Measures
Small
Spill: Use appropriate
tools to put the spilled solid in a convenient waste disposal container.
Large
Spill: Poisonous solid.
Stop leak if without risk. Do not get water inside container. Do not touch
spilled material. Use water spray to reduce vapors. Prevent entry into sewers,
basements or confined areas; dike if needed. Eliminate all ignition sources.
Call for assistance on disposal.
Section
7: Handling and Storage Precautions:
Keep
locked up. Keep away from heat. Keep away from sources of ignition. Empty
containers pose a fire risk, evaporate the residue under a fume hood. Ground all
equipment containing material. Do not ingest. Do not breathe dust. In case of
insufficient ventilation, wear suitable respiratory equipment. If ingested, seek
medical advice immediately and show the container or the label. Avoid contact
with skin and eyes.
Storage:
Keep container tightly
closed. Keep container in a cool, well-ventilated area.
Section
8: Exposure Controls/Personal Protection Engineering Controls:
Use
process enclosures, local exhaust ventilation, or other engineering controls to
keep airborne levels below recommended exposure limits. If user operations
generate dust, fume or mist, use ventilation to keep exposure to airborne
contaminants below the exposure limit.
Personal
Protection: Splash
goggles. Lab coat. Dust respirator. Be sure to use an approved/certified
respirator or equivalent. Gloves.
Personal
Protection in Case of a Large Spill: Splash
goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing
apparatus should be used to avoid inhalation of the product. Suggested
protective clothing might not be sufficient; consult a specialist BEFORE
handling this
product.
Exposure
Limits: Not available.
Section
9: Physical and Chemical Properties
Physical
state and appearance: Solid.
(Crystalline solid.)
Odor:
Not available.
Taste:
Not available.
Molecular
Weight: 281.34 g/mole
Color:
Colorless.
pH
(1% soln/water): Not
available.
Boiling
Point: Decomposes.
Melting
Point: 120°C (248°F)
Critical
Temperature: Not
available.
Specific
Gravity: Not available.
Vapor
Pressure: Not applicable.
Vapor
Density: Not available.
Volatility:
Not available.
Odor
Threshold: Not available.
Water/Oil
Dist. Coeff.: Not
available.
Ionicity
(in Water): Not available.
Dispersion
Properties: See solubility
in water, methanol, diethyl ether, acetone.
Solubility:
Soluble in methanol,
diethyl ether, acetone. Very slightly soluble in cold water.
Section
10: Stability and Reactivity Data
Stability:
The product is stable.
Instability
Temperature: Not
available.
Conditions
of Instability: Not
available.
Incompatibility
with various substances: Not
available.
Corrosivity:
Not available.
Special
Remarks on Reactivity: Not
available.
Special
Remarks on Corrosivity: Not
available.
Polymerization:
Will not occur.
Section
11: Toxicological Information
Routes
of Entry: Absorbed through
skin. Eye contact. Inhalation. Ingestion.
Toxicity
to Animals: Acute oral
toxicity (LD50): 2 mg/kg [Rat].
Chronic
Effects on Humans: DEVELOPMENTAL
TOXICITY: Classified Reproductive system/toxin/female, Development toxin
[POSSIBLE]. Causes damage to the following organs: the nervous system, liver.
May cause damage to the following organs: blood, kidneys, gastrointestinal
tract, skin.
Other
Toxic Effects on Humans: Very
hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special
Remarks on Toxicity to Animals: Not
available.
Special
Remarks on Chronic Effects on Humans: Embryotoxic
and/or foetotoxic in animal.
Special
Remarks on other Toxic Effects on Humans: Not
available.
Section
12: Ecological Information
Ecotoxicity:
Not available.
BOD5
and COD: Not available.
Products
of Biodegradation: Possibly
hazardous short term degradation products are not likely. However, long term
degradation products may arise.
Toxicity
of the Products of Biodegradation: The
products of degradation are as toxic as the original product.
Special
Remarks on the Products of Biodegradation: Not
available.
Section
13: Disposal Considerations
Waste
Disposal:
Section
14: Transport Information
DOT
Classification: CLASS 6.1:
Poisonous material.
Identification:
: Toxic solid, organic,
n.o.s. (Cycloheximide) UNNA: 2811 PG: I
Special
Provisions for Transport: Not
available.
Section
15: Other Regulatory Information Federal and State Regulations:
California
prop. 65: This product contains the following ingredients for which the State of
California has found to cause cancer, birth defects or other reproductive harm,
which would require a warning under the statute: Cycloheximide California prop.
65: This product contains the following ingredients for which the State of
California has found to cause birth defects which would require a warning under
the statute: Cycloheximide Pennsylvania RTK: Cycloheximide Florida:
Cycloheximide Michigan critical material: Cycloheximide Massachusetts RTK:
Cycloheximide New Jersey: Cycloheximide SARA 302/304/311/312 extremely hazardous
substances: Cycloheximide CERCLA: Hazardous substances.: Cycloheximide: 1 lbs.
(0.4536 kg)
Other
Regulations: OSHA:
Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial
Chemical Substances.
Other
Classifications:
WHMIS
(Canada): CLASS D-1A:
Material causing immediate and serious toxic effects (VERY TOXIC). CLASS D-2A:
Material causing other toxic effects (VERY TOXIC).
DSCL
(EEC): R28- Very toxic if
swallowed. R38- Irritating to skin. R40- Possible risks of irreversible effects.
R41- Risk of serious damage to eyes. R62- Possible risk of impaired fertility.
R63- Possible risk of harm to the unborn child.
HMIS
(U.S.A.):
Health
Hazard: 3
Fire
Hazard: 1
Reactivity:
0
Personal
Protection: E
National
Fire Protection Association (U.S.A.):
Health:
3
Flammability:
1
Reactivity:
0
Specific
hazard:
Protective
Equipment: Gloves. Lab
coat. Dust respirator. Be sure to use an approved/certified respirator or
equivalent. Wear appropriate respirator when ventilation is inadequate. Splash
goggles.
Section
16: Other Information
References:
Not available.
Other
Special Considerations: Not
available.
Product
Use: Laboratory
Reagent.
Disclaimer: Nile Chemicals. provides the
information contained herein in good faith but makes no representation as to its
comprehensiveness or accuracy. This document is intended only as a guide to the
appropriate precautionary handling of the material by a properly trained person
using this product. Individuals receiving the information must exercise their
independent judgment in determining its appropriateness for a particular
purpose. NILE CHEMICALS. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS
OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH
HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, NILE
CHEMICALS. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE
UPON THIS INFORMATION.
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