NILE
CHEMICALS
NILE
CHEMICALS
Section
1: Chemical Product and Company Identification
Product
Name: 8-Hydroxyquinoline
CAS#:
148-24-3
Synonym:
Oxine; 8-Hydroxyquinoline
Chemical
Name: 8-Quinolinol
Chemical
Formula: C9H7NO
Section
2: Composition and Information on Ingredients Composition:
Name
CAS #
% by Weight
{8-}Hydroxyquinoline
AR
148-24-3
100
Toxicological
Data on Ingredients: 8-Hydroxyquinoline:
ORAL (LD50): Acute: 1200 mg/kg [Rat]. 20000 mg/kg [Mouse]. DUST (LC50): Acute:
>1210 mg/m 6 hours [Rat].
Section
3: Hazards Identification Potential Acute Health Effects:
Hazardous
in case of ingestion, of inhalation. Slightly hazardous in case of skin contact
(irritant, permeator), of eye contact (irritant).
Potential
Chronic Health Effects:
CARCINOGENIC
EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic
for mammalian somatic cells. Mutagenic for bacteria and/or yeast. TERATOGENIC
EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may
be toxic to central nervous system (CNS). Repeated or prolonged exposure to the
substance can produce target organs damage.
Section
4: First Aid Measures Eye Contact:
Check
for and remove any contact lenses. In case of contact, immediately flush eyes
with plenty of water for at least 15 minutes. Get medical attention if
irritation occurs.
Skin
Contact: Wash with soap
and water. Cover the irritated skin with an emollient. Get medical attention if
irritation develops.
Serious
Skin Contact: Not
available.
Inhalation:
If inhaled, remove to
fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Get medical attention.
Serious
Inhalation: Not available.
Ingestion:
Do NOT induce vomiting
unless directed to do so by medical personnel. Never give anything by mouth to
an unconscious person. If large quantities of this material are swallowed, call
a physician immediately. Loosen tight clothing such as a collar, tie, belt or
waistband.
Serious
Ingestion: Not available.
Section
5: Fire and Explosion Data
Flammability
of the Product: May be
combustible at high temperature.
Auto-Ignition
Temperature: Not
available.
Flash
Points: Not available.
Flammable
Limits: Not available.
Products
of Combustion: These
products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire
Hazards in Presence of Various Substances:
Slightly
flammable to flammable in presence of open flames and sparks, of heat.
Non-flammable in presence of shocks.
Explosion
Hazards in Presence of Various Substances:
Risks
of explosion of the product in presence of mechanical impact: Not available.
Slightly explosive in presence of open flames and sparks.
Fire
Fighting Media and Instructions:
SMALL
FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not
use water jet.
Special
Remarks on Fire Hazards: When
heated to decomposition it emits highly toxic fumes.
Special
Remarks on Explosion Hazards:
Fine
dust dispersed in air in sufficient concentrations, and in presence of an
ignition source, is a potential dust explosion hazard.
Section
6: Accidental Release Measures Small Spill:
Use
appropriate tools to put the spilled solid in a convenient waste disposal
container. Finish cleaning by spreading water on the contaminated surface and
dispose of according to local and regional authority requirements.
Large
Spill:Use a shovel to put
the material into a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and allow to evacuate through the
sanitary system.
Section
7: Handling and Storage Precautions:
Keep
locked up.. Keep away from heat. Keep away from sources of ignition. Empty
containers pose a fire risk, evaporate the residue under a fume hood. Ground all
equipment containing material. Do not ingest. Do not breathe dust. Wear suitable
protective clothing. In case of insufficient ventilation, wear suitable
respiratory equipment. If ingested, seek medical advice immediately and show the
container or the label. Keep away from incompatibles such as oxidizing agents,
acids.
Storage:Keep
container tightly closed. Keep container in a cool, well-ventilated area.
Sensitive to light. Store in light-resistant containers.
Section
8: Exposure Controls/Personal Protection Engineering Controls:
Use
process enclosures, local exhaust ventilation, or other engineering controls to
keep airborne levels below recommended exposure limits. If user operations
generate dust, fume or mist, use ventilation to keep exposure to airborne
contaminants below the exposure limit.
Personal
Protection: Safety
glasses. Lab coat. Dust respirator. Be sure to use an approved/certified
respirator or equivalent. Gloves.
Personal
Protection in Case of a Large Spill:
Splash
goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing
apparatus should be used to avoid inhalation of the product. Suggested
protective clothing might not be sufficient; consult a specialist BEFORE
handling this product.
Exposure
Limits: Not available.
Section
9: Physical and Chemical Properties
Physical
state and appearance: Solid.
(Solid crystalline powder.)
Odor:
Phenolic
Taste:
Not available.
Molecular
Weight: 145.16 g/mole
Color:
White.
pH
(1% soln/water): Not
applicable.
Boiling
Point: 267°C (512.6°F)
Melting
Point: 74°C (165.2°F)
Critical
Temperature: Not
available.
Specific
Gravity: 1.04 (Water = 1)
Vapor
Pressure: Not applicable.
Vapor
Density: Not available.
Volatility:
Not available.
Odor
Threshold: Not available.
Water/Oil
Dist. Coeff.: Not
available.
Ionicity
(in Water): Not available.
Dispersion
Properties: See solubility
in water, acetone.
Solubility:
Easily soluble in acetone.
Insoluble in cold water, hot water. Freely soluble in alcohol, benzene,
chloroform, and aqueous mineral acids. Soluble in acetic, formic, hydrochloric,
and sulfuric acids, and in alkalies.
Section
10: Stability and Reactivity Data
Stability:
The product is stable.
Instability
Temperature: Not
available.
Conditions
of Instability: Excess
heat, incompatible materials, excess dust generation, light
Incompatibility
with various substances: Reactive
with oxidizing agents, acids.
Corrosivity:
Non-corrosive in presence
of glass.
Special
Remarks on Reactivity: Sensitive
to light. It darkens when exposed to light.
Special
Remarks on Corrosivity: Not
available.
Polymerization:
Will not occur.
Section
11: Toxicological Information
Routes
of Entry: Inhalation.
Ingestion.
Toxicity
to Animals: WARNING: THE
LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute
oral toxicity (LD50): 1200 mg/kg [Rat]. Acute toxicity of the dust (LC50):
>1210 mg/m3 6 hours [Rat].
Chronic
Effects on Humans:
CARCINOGENIC
EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: Mutagenic
for mammalian somatic cells. Mutagenic for bacteria and/or yeast. May cause
damage to the following organs: central nervous system (CNS).
Other
Toxic Effects on Humans: Hazardous
in case of ingestion, of inhalation. Slightly hazardous in case of skin contact
(irritant, permeator).
Special
Remarks on Toxicity to Animals: Not
available.
Special
Remarks on Chronic Effects on Humans:
May
affect genetic material (mutagenic). May cause cancer based on animal data. No
human data found.
Special
Remarks on other Toxic Effects on Humans:
Acute
Potential Health Effects: Skin: Causes skin irritation. Eyes: Causes eye
irritation. Inhalation: May be harmful if inhaled. Causes respiratory tract and
mucous membrane irritation. Symptoms may include coughing, labored breathing,
and chest pain. Other effects may parallel those of ingestion. Ingestion: May
harmful if swallowed. May cause gastrointestinal tract irritation with nausea,
vomiting and diarrhea. Ingestion of large oral doses may affect behavior/central
nervous system (confusion, paralysis), respiration (breathing difficulty),
metabolism (anorexia - weight loss or decreased weight gain), and may cause
malaise. Chronic Potential Health Effects: Ingestion: Repeated or prolonged
ingestion will also have effects similar to those of acute ingestion.
Section
12: Ecological Information
Ecotoxicity:
Not available.
BOD5
and COD: Not available.
Products
of Biodegradation:
Possibly
hazardous short term degradation products are not likely. However, long term
degradation products may arise.
Toxicity
of the Products of Biodegradation: The
products of degradation are less toxic than the product itself.
Special
Remarks on the Products of Biodegradation: Not
available.
Section
13: Disposal Considerations
Waste
Disposal:
Waste
must be disposed of in accordance with federal, state and local environmental
control regulations.
Section
14: Transport Information
DOT
Classification: Not a DOT
controlled material
Identification:
Not applicable.
Special
Provisions for Transport: Not
applicable.
Section
15: Other Regulatory Information
Federal
and State Regulations: TSCA
8(b) inventory: 8-Hydroxyquinoline
Other
Regulations: OSHA:
Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other
Classifications:
WHMIS
(Canada): Not controlled
under WHMIS (Canada).
DSCL
(EEC): R20/22- Harmful by
inhalation and if swallowed. R36/37/38- Irritating to eyes, respiratory system
and skin. R40- Possible risks of irreversible effects. S2- Keep out of the reach
of children. S24/25- Avoid contact with skin and eyes. S46- If swallowed, seek
medical advice immediately and show this container or label.
HMIS
(U.S.A.):
Health
Hazard: 2
Fire
Hazard: 1
Reactivity:
0
Personal
Protection: E
National
Fire Protection Association (U.S.A.):
Health:
2
Flammability:
1
Reactivity:
0
Specific
hazard:
Protective
Equipment: Gloves. Lab
coat. Dust respirator. Be sure to use an approved/certified respirator or
equivalent. Safety glasses.
Disclaimer: Nile Chemicals. provides the
information contained herein in good faith but makes no representation as to its
comprehensiveness or accuracy. This document is intended only as a guide to the
appropriate precautionary handling of the material by a properly trained person
using this product. Individuals receiving the information must exercise their
independent judgment in determining its appropriateness for a particular
purpose. NILE CHEMICALS. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS
OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH
HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, NILE
CHEMICALS. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE
UPON THIS INFORMATION.
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