NILE CHEMICALS

SAFETY DATA SHEET

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product identifiers

Product name : 4-Aminoantipyrine

Product Number :

Brand : Nile

CAS-No. : 83-07-8

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet

Company : Nile Chemical

Masjid Bunder Mumbai INDIA

Telephone : 66313162

1.4 Emergency telephone number

Emergency Phone # : +91-2266313162  

2. HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]

Acute toxicity, Oral (Category 4)

Skin irritation (Category 2)

Eye irritation (Category 2)

Specific target organ toxicity - single exposure (Category 3)

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Harmful if swallowed. Irritating to eyes, respiratory system and skin.

2.2 Label elements

Signal word Warning

Hazard statement(s)

H302 Harmful if swallowed.

H315 Causes skin irritation.

H319 Causes serious eye irritation.

H335 May cause respiratory irritation.

Precautionary statement(s)

P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing.

Supplemental Hazard none

Statements

Safety data sheet available on request.

According to European Directive 67/548/EEC as amended.

Hazard symbol(s)

R-phrase(s)

R22 Harmful if swallowed.

R36/37/38 Irritating to eyes, respiratory system and skin.

S-phrase(s)

S26 In case of contact with eyes, rinse immediately with plenty of water and

seek medical advice.

S36 Wear suitable protective clothing.

2.3 Other hazards - none

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

Synonyms : 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one

Ampyrone

Formula : C11H13N3O

Molecular Weight : 203,24 g/mol

Component Concentration

4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one

CAS-No.  EC-No. 

83-07-8    201-452-3

4. FIRST AID MEASURES

4.1 Description of first aid measures

General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

To the best of our knowledge, the chemical, physical, and toxicological properties have not been

thoroughly investigated.

4.3 Indication of any immediate medical attention and special treatment needed

no data available

5. FIREFIGHTING MEASURES

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx)

5.3 Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

5.4 Further information

no data available

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure

adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

6.2 Environmental precautions

Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed

containers for disposal.

6.4 Reference to other sections

For disposal see section 13.

7. HANDLING AND STORAGE

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.

Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire

protection.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

hygroscopic Light sensitive.

7.3 Specific end uses

no data available

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1 Control parameters

Components with workplace control parameters

8.2 Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and

at the end of workday.

Personal protective equipment

Eye/face protection

Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested

and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique

(without touching glove's outer surface) to avoid skin contact with this product. Dispose of

contaminated gloves after use in accordance with applicable laws and good laboratory practices.

Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and

the standard EN 374 derived from it.

Immersion protection

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm

Break through time: > 480 min

Material tested:Dermatril® (Aldrich Z677272, Size M)

Splash protection

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm

Break through time: > 30 min

Material tested:Dermatril® (Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000, e-mail sales@kcl.de,

test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374,

contact the supplier of the CE approved gloves. This recommendation is advisory only and must

be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our

customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected

according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher

level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.

Use respirators and components tested and approved under appropriate government standards

such as NIOSH (US) or CEN (EU).

9. PHYSICAL AND CHEMICAL PROPERTIES

9.1 Information on basic physical and chemical properties

a) Appearance Form: solid

b) Odour no data available

c) Odour Threshold no data available

d) pH no data available

e) Melting point/freezing

point

Melting point/range: 105 - 110 °C - lit.

f) Initial boiling point and

boiling range

no data available

g) Flash point no data available

h) Evaporation rate no data available

i) Flammability (solid, gas) no data available

j) Upper/lower

flammability or

explosive limits

no data available

k) Vapour pressure no data available

l) Vapour density no data available

m) Relative density no data available

n) Water solubility no data available

o) Partition coefficient: noctanol/

water

no data available

p) Autoignition

temperature

no data available

q) Decomposition

temperature

no data available

r) Viscosity no data available

s) Explosive properties no data available

t) Oxidizing properties no data available

9.2 Other safety information

no data available

10. STABILITY AND REACTIVITY

10.1 Reactivity

no data available

10.2 Chemical stability

no data available

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong oxidizing agents, Strong acids, Acid chlorides, Acid anhydrides

10.6 Hazardous decomposition products

Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects

Acute toxicity

LD50 Oral - rat - 1.700 mg/kg

Inhalation: no data available

Skin corrosion/irritation

no data available

Serious eye damage/eye irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

Genotoxicity in vitro - Histidine reversion (Ames)

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as

probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

no data available

Specific target organ toxicity - single exposure

Inhalation - May cause respiratory irritation.

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard

no data available

Potential health effects

Inhalation May be harmful if inhaled. Causes respiratory tract irritation.

Ingestion Harmful if swallowed.

Skin May be harmful if absorbed through skin. Causes skin irritation.

Eyes Causes serious eye irritation.

Signs and Symptoms of Exposure

To the best of our knowledge, the chemical, physical, and toxicological properties have not been

thoroughly investigated.

Additional Information

RTECS: CD2480000

12. ECOLOGICAL INFORMATION

12.1 Toxicity

no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Results of PBT and vPvB assessment

no data available

12.6 Other adverse effects

no data available

13. DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed

professional waste disposal service to dispose of this material. Dissolve or mix the material with a

combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging

Dispose of as unused product.

14. TRANSPORT INFORMATION

14.1 UN number

ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name

ADR/RID: Not dangerous goods

IMDG: Not dangerous goods

IATA: Not dangerous goods

14.3 Transport hazard class(es)

ADR/RID: - IMDG: - IATA: -

14.4 Packaging group

ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user

no data available

15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

no data available

15.2 Chemical Safety Assessment

no data available

16. OTHER INFORMATION

Further information

The above information is believed to be correct but does not purport to be all inclusive and shall be

used only as a guide. The information in this document is based on the present state of our knowledge

and is applicable to the product with regard to appropriate safety precautions. It does not represent any

guarantee of the properties of the product. Nile Chemicals and its Affiliates shall not be held

liable for any damage resulting from handling or from contact with the above product.

PRODUCT LIST

nilesh@nilechemicals.com

sales@nilechemicals.com